Abaloparatide increases bone mineral density and bone strength in ovariectomized rabbits with glucocorticoid-induced osteopenia.

Mechanistically, improved femoral diaphyseal thickness and vBMD in the ABL25 group may be best explained by abaloparatide effects on the endocortical and intracortical envelopes: there was no evidence for increased periosteal apposition in the ABL25 group based on femoral diaphyseal Tt.Ar results, whereas the ABL25 group showed a trend toward reduced marrow area (a proxy for increased endocortical apposition), with a relative reduction of 4% vs GC-OVX controls ( P = 0.07), and a non-significant relative reduction in cortical porosity of 53% vs GC-OVX controls ( P = 0.30).

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