Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment.

Mol Metab · 2019 · PMC6667392 · PMID 31176677

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Furthermore, mRNA expression of the T3 responsive gene Hr [30] showed a trend towards an increase after 2 days of Cort ( Figure 4 C,D). 3.6 Dio2 knockdown in the mediobasal hypothalamus using AAV-mediated CRISPR-Cas9 To investigate the role of elevated Dio2 in the development of GC-induced metabolic effects, we next sought to knock down Dio2 in the MBH using AAV-mediated CRISPR-Cas9.

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