BiP S + /K − lacking the KDEL ER retention sequence also showed a trend towards a lower ATPase activity than full‐length (S + /K + ) BiP, but the difference was not found to be significant (Fig. 3 ).
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ATPase activity of human binding immunoglobulin protein (BiP) variants is enhanced by signal sequence and physiological concentrations of Mn<sup>2</sup>.
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