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Mitochondrial disorders and drugs: what every physician should know.

Drugs Context · 2019 · PMC6668504 · PMID 31391854

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14 Several measures showed a trend toward improvement on treatment. 14 In another more recent crossover trial, 30 patients with MD received coenzyme Q10 (1200 mg/day) for 60 days. 15 The treatment had some effects on aerobic capacity and postexercise lactate, without affecting other relevant variables. 15 Unfortunately, crystalline CoQ10 is lipophilic, water insoluble, and poorly absorbed in the gut. 16 Therefore, there is a strong need for using solubilized formulations with certified bioavailability.

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