Amplicon-based microbiome study highlights the loss of diversity and the establishment of a set of species in patients with dentin caries.

Our data displayed a highly significant difference in alpha diversity between the groups (p<0.001) and a significantly higher dominance in the diseased samples versus healthy samples (p<0.001) (Figs 5 and 6 ).

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With p = 0.066 it was, compared with the other parameters, the one with the highest tendency towards significance ( Table 2 ).

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