Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers.

Our findings are comparable with those of an earlier study that reported increased AST to ALT ratio values and lower levels of ALT in patients with AD compared with controls, although in that study, the association between AD and ALT levels did not reach statistical significance. 40 Altered liver enzymes lead to disturbances in liver-associated metabolites including branched-chain amino acids, ether-phosphatidylcholines, and lipids, 41 which we and others show are altered in AD 1 , 42 , 43 , 44 and may play a role in disease pathophysiologic characteristics. 45 Disturbed e

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