Labile Calcium-Permeable AMPA Receptors Constitute New Glutamate Synapses Formed in Hypothalamic Neuroendocrine Cells during Salt Loading.

There was a highly significant correlation between membrane capacitance and NAS sensitivity of the eEPSCs in the SON neurons (correlation coefficient = 0.8, n = 19, p < 0.001; Fig. 5 ).

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Using Western blot analysis of crosslinked surface protein and unmodified intracellular protein, we found that both the surface and intracellular GluA1 protein levels increased in the salt-loaded animals (51% and 73% increase, respectively, compared to controls), although the increase in intracellular GluA1 did not reach statistical significance ( p = 0.137; Fig. 2 C ).

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