Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G<sub>2</sub> Arrest and Highly Effective Evasion of Innate Immune Sensing.

In mock-infected RPTE cells, all three inhibitors produced the expected effects: PD0332991 increased the proportion of cells in G 1 from 72% to 84% ( P < 0.05), Roscovitine produced little change in the proportion of cells in any cell cycle phase because of its broad effect on S, G 2 and M phases, and RO-3306 produced an increased proportion of cells in G 2 /M (18% to 23%) and reduced proportion in G 1 (72% to 65%) although this did not reach statistical significance ( Fig. 8A and B ).

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