High Constitutive Cytokine Release by Primary Human Acute Myeloid Leukemia Cells Is Associated with a Specific Intercellular Communication Phenotype.

Firstly, we observed a highly significant association between NPM1 and DNA methylation gene mutations (Fisher’s Exact test, p = 0.0015), whereas the association between FLT3 -ITD and NPM1 mutations did not reach significance.

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Finally, even in this relatively small patient cohort, we observed that no patients with TET2 mutations (13 patients) had IDH mutation (5 patients); this inverse correlation has been described in previous cohorts [ 6 ], but did not reach statistical significance in our smaller cohort.

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