Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts.

Quantification of luminescence derived from the metastases revealed a dramatic and significant reduction in metastatic burden in mice provided SLC-0111 compared to animals administered sunitinb or vehicle and showed a trend toward reduced metastasis in animals administered combination therapy ( Figure 1 e).

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