Concentration Effects in the Interaction of Monoclonal Antibodies (mAbs) with their Immediate Environment Characterized by EPR Spectroscopy.

Moreover, there is a clear trend in the spectra, as revealed through their simulations ( Figure 2 ) of an increasing fraction (~55%) of a CAT1 species experiencing a more hydrophobic environment in the buffer, which leads to a decrease in δA iso of about 1 MHz, and slowed dynamics confirmed by a considerable increase of the τ c .

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