A study of 125 children and adolescents with obesity showed a trend toward lower 25(OH)D levels being associated with low adiponectin levels and higher insulin resistance even after adjusting for body mass, though there was no correlation between 25(OH)D levels and resistin [ 145 ].
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However, a meta-analysis that included five RCTs in patients with RA reported borderline significance for reduction in disease recurrence, but not for disease activity [ 84 ].