Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.

Injection of the anti-CII mAb M2139 alone, the most arthritogenic antibody in the cocktail, also reduced total movement compared with the isotype IgG2b control antibody, although the difference in rearing between the groups did not reach statistical significance (P = 0.054; Fig. 2 H ).

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