Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis.

PLoS Med · 2019 · PMC6684046 · PMID 31386659

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did not reach statistical significancep = 0.09so close (0.05 < p ≤ 0.1)

Children of mothers treated with metformin during pregnancy tended to be heavier than children of mothers treated with insulin during pregnancy, but this difference did not reach statistical significance (mean difference 1.13 kg, 95% CI −0.19 to 2.45, I 2 = 20%, p = 0.09) ( Fig 13 ).

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