Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A Systems Genetics Analysis.

Front Cardiovasc Med · 2019 · PMC6684968 · PMID 31417910

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0867

boldest claim

The sentences

borderline significancep = 7.69e−06actually significant

Moreover, Jmjd1a , a histone 3 lysine 9 (H3K9)-specific demethylase that binds all 3 myocardin family members, was positively correlated with A velocity at week 3 with borderline significance ( r = 0.457, p = 7.69e−06, BH adjusted p = 0.0549) and is known to be upregulated in myocardium from patients with hypertrophic heart disease ( 21 ).

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showed a trendp = 0.0867so close (0.05 < p ≤ 0.1)

Hus1 expression under the control condition showed a trend to positive correlation with E/A ratio (cor = 0.193, p = 0.0867) and mapped to the same locus as E/A ratio, indicative of a cis-eQTL that may underly the phenotype of week 0 E/A ratio.

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