Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies.

Front Immunol · 2019 · PMC6685135 · PMID 31417564

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showed a trendno p-value reported

In the absence of hCEA the 1D8 N/C CEA.1 showed a costimulatory effect similar to 1D8 N18 , but in the presence of immobilized hCEA T cell proliferation was significantly increased ( P = 0.003), whereas IFNγ secretion showed a trend to increase, without statistical significance ( Figures 5D,E ).

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