In a 2016 study of 40 PWH with 58% of PWH on ART, a nearly significant elevation of CSF C1q expression was observed in cognitively impaired subjects between 18 and 24 years old compared to cognitively normal subjects, and within the PWH group, CSF C1q correlated with CSF NFL levels (McGuire et al., 2016 ).
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HIV-Associated Neurocognitive Impairment in the Modern ART Era: Are We Close to Discovering Reliable Biomarkers in the Setting of Virological Suppression?
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