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Keap1/Nrf2 Signaling: A New Player in Thyroid Pathophysiology and Thyroid Cancer.

Front Endocrinol (Lausanne) · 2019 · PMC6687762 · PMID 31428048

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a near-significant trendno p-value reported
In contrast, expression of heme oxygenase-1 (HO-1), another target gene of Nrf2 ( 69 ), was found to correlate with thyroid cancer aggressiveness (stage and risk of recurrence, plus a near-significant trend for extra-thyroidal invasion), but not with tumor size or lymph node metastasis ( 70 ).

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