GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis.

Nat Med · 2019 · PMC6689469 · PMID 31332391

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a positive trendno p-value reported

We also observed slightly increased GM-CSF expression by γδ T cells and a positive trend in B cells, however not in NK cells or CD8 + T cells.

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a negative trendno p-value reported

We then interrogated the influence of aging on cytokine production and found that while most of the analyzed cytokines show a positive correlation with age ( 22 ), GM-CSF and IL-6 production by PBMCs display a negative trend ( Extended Data Fig.3A-C ).

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