Already two weeks after BDL, hepatic platelet derived growth factor (PDGF)-beta receptor transcription showed a trend towards lower mRNA levels in TGR(mREN2)27 rat livers, reaching significance four weeks after BDL and in the CCl 4 model (Fig. 1F ).
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TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor.
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