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Hydrocortisone Reduces 28-day Mortality in Septic Patients: A Systemic Review and Meta-analysis.

Cureus · 2019 · PMC6692095 · PMID 31423390

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a strong trendno p-value reported
Similarly, our sub-group analysis of the primary outcome on the basis of time to administration of hydrocortisone from randomization suggested a strong trend towards reduced mortality in the late administration group as compared to the early administration group (within eight hours vs. within 24 to 72 hours).

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