Unsurprisingly, at the first report of survival data from STAMPEDE, there was not a statistically significant improvement in OS for patients with nonmetastatic PC (hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.62–1.47), or evidence of heterogeneity of the treatment effect compared to metastatic PC; a meta-analysis of all randomised controlled trial data in non-metastatic patients showed a trend towards improvement in OS that does not reach statistical significance (HR 0.87, 95% CI 0.69–1.09) [8] .
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Addition of Docetaxel to First-line Long-term Hormone Therapy in Prostate Cancer (STAMPEDE): Modelling to Estimate Long-term Survival, Quality-adjusted Survival, and Cost-effectiveness.
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