Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits.

Pharmacogenomics J · 2019 · PMC6693985 · PMID 30760877

Europe PMC DOI

hedged sentences

0.0790

closest p · 1.6× alpha

0.0790

boldest claim

The sentences

marginal significanceP=0.079so close (0.05 < p ≤ 0.1)

For the remainder of candidate genes studied in European Caucasian subjects, we only observed significant association for ARRB2 with low maximum pain phenotype (P=0.026) and marginal significance of OPRM1 (P=0.079) and COMT (P=0.057) with total morphine sulfate dose.

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of marginal significanceno p-value reported

49 For children of African American descent rs4633 was of marginal significance with the T allele conferring reduced odds of having high pain.

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marginally significantno p-value reported

With significant and marginally significant associations representing multiple relational nodes across phenotype and race, our composite data suggest an important role for KCNJ6 in postoperative pain managed with morphine.

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