Case-control association analyses using clinically discordant DZ twins as both cases and controls, while underpowered, identified a large number of nominally significant SNPs associated with genes that are significantly enriched in autism risk genes.
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ASD Phenotype-Genotype Associations in Concordant and Discordant Monozygotic and Dizygotic Twins Stratified by Severity of Autistic Traits.
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The sentences
Similarly, a linkage analysis based on these subphenotypes revealed novel genetic loci with highly significant LOD scores that were not detected in the absence of subtyping in addition to intra-family phenotypic and genetic heterogeneity [ 20 ].