A comparison of CTL assay potency of DARTs 30, 20, PF, and 154, which have affinities within three-fold of one another ( Figure 4 C), showed a trend toward higher potency corresponding to more membrane-proximal epitopes.
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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
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