nominally significantP = 8.6 × 10 −3
The associations in MC4R (combined MAF = 0.79%, minimum P = 2.7 × 10 −10 , odds ratio = 2.07, 95% confidence interval = 1.65–2.59) and PAM (combined MAF = 4.9%, weighted P = 2.2 × 10 − 9 , odds ratio = 1.44, 95% confidence interval = 1.28–1.62) result largely from effects of the previously identified coding variants in these genes, although the MC4R signal remained nominally significant after removing Ile269Asn ( P = 8.6 × 10 −3 ; Supplementary Fig. 7 ) and the PAM signal remained nominally significant ( P < 0.05) after removing the 35 strongest individually associated PAM variants (Supplementary Fig. 8 ).