Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients.

4d , left); an increase in mutational frequency with age was highly significant for males ( p = 3.8 E − 5 ), but not for females.

also in 132,142 other papers

In addition, a marginally significant potential hotspot (E132; three mutations, p = 0.018) is located in the α-helix between two amino acid motifs (G4, NKXD and G5, EXSAK) that are important for binding the guanine base of the nucleotide 32 .

also in 26,082 other papers

For HRAS, no new hotspots were unequivocally identified, although two residues (R164 and P167) were borderline significant (Fig. 2c ).

also in 11,409 other papers

However, these findings did not reach statistical significance due to lower overall numbers, with only 44/235 (18.5%) of MT-H patients <40 years (Supplementary Fig. 4c ); further, trends based on analysis of age as continuous variable were not conclusive (Supplementary Fig. 4d ).

also in 111,027 other papers