This trend was also observed in the upregulated DEGs for pgrn-1(-) ; granulin 1(+) ( P = 0.149) and pgrn-1(-) ; granulin 2(+) ( P = 0.097) but did not reach statistical significance.
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Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.
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