Anomalous enhancement of resurgent Na⁺ currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgia.

In the functional categories of SF–36 questionnaires, the patients reported a clear trend of limitations in physical function and in health related to pain in summer (ambient temperature 27.7–29.6 °C in Taiwan) than in winter (16.1–17.9 °C) (Supplementary Data Table 1 ).

also in 19,460 other papers