Effect of different methods of cooling for targeted temperature management on outcome after cardiac arrest: a systematic review and meta-analysis.

In the largest multicenter RCT available to date, which compared EC to basic external methods (i.e., non-invasive, without TFD, n = 400), favorable neurological outcome at day 28 was not significantly different between the groups [ 12 ], although a strong trend towards a higher occurrence of intact neurological recovery at day 90 was observed in the EC group (odds ratio 1.51; 95% CIs 0.96–2.35; p = 0.07).

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