Bacterial load and inflammatory response in sputum of alpha-1 antitrypsin deficiency patients with COPD.

10 However, we did not find markedly significant differences in sputum CXCL8 levels between AATD-AT patients and cigarette smoke-associated COPD patients with a similar degree of airflow obstruction, suggesting that augmentation therapy reduces sputum neutrophilia in these patients, thus acting with other molecular mechanisms.

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aeruginosa showed a trend to be increased in cigarette smoke-associated COPD, AATD-noT and AATD-AT with respect to CON confirming earlier studies using different methods. 16 , 26 , 38 M. catarrhalis and S. pneumoniae copies/ml were increased in cigarette smoke-associated COPD compared to CON and significantly decreased in AATD-AT, having a similar degree of airflow obstruction.

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