Asian Subpopulations May Exhibit Greater Cardiovascular Benefit from Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A Meta-Analysis of Cardiovascular Outcome Trials.

Although the reduction in risk of MACE observed in the EXSCEL trial did not reach statistical significance as a single study, the combined analysis of all three CVOTs revealed statistically significant MACE risk reductions (relative risk [RR], 0.88; 95% CI, 0.81 to 0.97) ( Fig. 1A ).

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Of note, our subgroup analysis revealed a differential CV benefit of GLP-1 RAs across ethnic groups with a favorable trend towards Asians.

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