This study was conducted among older white and black adults from the Health, Aging and Body Composition (Health ABC) study, and it reported a marginally significant association for T2DM risk per 1-log increment of fetuin-A levels (OR, 1.57; 95% CI, 0.99 to 2.49) [ 7 ].
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Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study.
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When stratified by HbA1c levels, the association between fetuin-A and T2DM risk remained strong among those with baseline HbA1c ≥6.5% (OR comparing extreme quintiles of fetuin-A was 2.47; 95% CI, 1.15 to 5.29), whereas the association did not reach statistical significance among those with HbA1c levels <6.5% (OR comparing extreme quintiles of fetuin-A was 1.85; 95% CI, 0.84 to 4.08) ( Supplementary Table 2 ).