Thrombin-Activatable Fibrinolysis Inhibitor Polymorphisms and Cerebral Venous Thrombosis in Mexican Mestizo Patients.

26 A previous meta-analysis examined the association between the Thr325Ile SNP and coronary artery disease, with an increased global risk association (OR = 1.25, 95% CI, 1.02-1.54) in mixed ethnic groups; however, in a subgroup analysis of European cases, this association did not reach statistical significance (OR = 1.13, 95% CI, 0.90-1.40). 29 The Mexican Mestizo genetic pool (Amerindian, Hispanic Caucasian, and African) could play a role in elucidating the SNP behavior of the TAFI gene and associated risk association for CVT. 30 In a previous report from Zorio et al, 31 Thr325Ile SNP frequencies were similar among cases with myocardial infarction and controls in a young Hispanic sample, with an increase in TAFI activity in cases not related to the SNP distribution.

also in 111,027 other papers