Associations of the SLCO1B1 Polymorphisms With Hepatic Function, Baseline Lipid Levels, and Lipid-lowering Response to Simvastatin in Patients With Hyperlipidemia.

35 However, conflicting results from Shabana et al indicated that participants with the GG genotype had higher baseline HDL-C levels than the participants with AA and AG genotypes, although this difference did not reach statistical significance with a small sample size of just 50 participants. 15 Despite their excellent lipid-lowering efficacy, statins remain underused in clinical practice, partly because of concerns over adverse drug events affecting the musculoskeletal system. 38 , 39 Thus, our current study also investigated the association between statin-induced elevations in serum creatine kinase (CK) levels and the SLCO1B1 gene polymorphisms.

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