Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy.

Pathway enrichment analyses 38 for the genes in this community showed highly significant enrichments for oestrogen response, TNFα signalling, epithelial–mesenchymal transition and the p53 pathway (Fig. 3f ; q -value < 1e-8).

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These results further corroborate our previous observations that these genes tend to be controlled by the same GRNs, and showed a trend of higher expression in luminal tumours with longer latency of recurrence (A vs B; Supplementary Fig. 8d ).

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