ADAM17-Mediated Reduction in CD14<sup>++</sup>CD16<sup>+</sup> Monocytes <i>ex vivo</i> and Reduction in Intermediate Monocytes With Immune Paresis in Acute Pancreatitis and Acute Alcoholic Hepatitis.

Culture for 24 h also led to a reduction in IFNα-induced STAT1 phosphorylation ( Figure 7B ), a strong trend toward a reduction in LPS-induced TNFα, significantly reduced IL-6 production ( Figures 7C,D ), and increased LPS-induced expression of the anti-inflammatory cytokine IL-10 ( Figure 7E ).

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Incubation with TMI005 prevented LPS and poly I:C induced reduction of cells in the intermediate monocyte gate, with a similar trend toward significance for flagellin ( ns = not statistically significant).

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