Hypothalamic mTORC2 is essential for metabolic health and longevity.

The effect in females was absent after dividing energy expenditure by body weight, but remained marginally significant when adjusting by ANCOVA.

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Using implanted telemetry probes, we observed a subtle but consistent reduction in core body temperature in ad libitum fed female Rictor Nkx2.1−/− mice during the middle of the dark period, with a similar tendency that did not reach statistical significance in males (Figure S6 a–d).

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