How to Deal with Second Line Dilemma in Metastatic Colorectal Cancer? A Systematic Review and Meta-Analysis.

Cancers (Basel) · 2019 · PMC6721481 · PMID 31443300

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

a significant trendp = 0.05actually significant

Our analysis reported also a significant trend towards ORR for anti-VEGF combinations (RR 1.46, 95% CI 1.00–2.12; p = 0.05).

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a positive trendno p-value reported

Patients from the studies PEAK, PRIME and Study 181 were included in the analysis and the results suggested a positive trend towards improved OS for first line panitumumab plus chemotherapy followed by second-line anti VEGF [ 19 ].

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