Risk-Reducing Bilateral Salpingo-Oophorectomy for BRCA Mutation Carriers and Hormonal Replacement Therapy: If It Should Rain, Better a Drizzle than a Storm.

Although these figures did not reach statistical significance, Kostopoulos et al. recorded an 8% reduction in breast cancer risk (HR, 0.92; 95% CI, 0.83–1.01) for every year of estrogen replacement and an 8% increase in breast cancer risk (HR,1.08; 95% CI, 0.92–1.27) for every year of progestin replacement.

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