A natural gene drive system influences bovine tuberculosis susceptibility in African buffalo: Possible implications for disease management.

When considered together, SAE indvO and SAE indvN alleles showed a highly significant frequency decrease in HiP in relation to association strength (Z-transform tests; rank differences: combined P = 0.0026, correlations: combined P = 0.00021; Tests 2 and 3 in Table 2 ).

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The interaction became near-significant ( P = 0.068, AIC = 262.7; Table 4 ), when also the average total per-locus frequency of the SAE indvN, A <1 alleles ( Table 3 ) was included as main factor, together with its interactions with 3yr-pre-birth rainfall and sex.

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