Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models.

Mol Ther · 2019 · PMC6731179 · PMID 31303442

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quite significantno p-value reported

12 The results showing the improved activity of ASO in some patient-derived CTCs via GalNAc conjugation are quite significant, in that they demonstrated a potential use of CTCs to select a subgroup of HCC patients whose tumors express functionally active ASGR and, thus, are likely to be sensitive to GalNAc-conjugated ASOs.

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