By using tyroxine hydroxylase (TH) immunostaining coupled to Adipo-Clear 28 , 29 , our data showed that central treatment with nicotine promoted a clear trend to increase the length, area and volume of the dendrites innervating gWAT (Fig. 2d and Supplementary Movie 1 ), which was indicative that besides promoting functional changes in sympathetic activity, nicotine also elicited changes in the plasticity and architecture of sympathetic fibers.
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Central nicotine induces browning through hypothalamic κ opioid receptor.
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