CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing.

Though all tested CAR constructs demonstrated equal activation and killing ability for either target, the CAR construct harboring the long extracellular spacer in combination with the CD28 co-stimulatory domain, tended to release higher amounts of effector cytokines, although this difference did not reach statistical significance While CD171 expression was completely lost on all cell lines following CAR-T cell treatment, GD2 was only down-regulated in cell lines initially harboring low GD2 levels.

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