Na_V1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age.

4J ), Scn2a +/+ and Scn2a +/− adult mice did not show any significant differences in the time spent immobile, although a tendency to decreased immobility time was observed for Scn2a +/− mice at the end of the 6-min session (two-way repeated measures ANOVA main, F(1, 26) = 3.15, p = 0.0875 for genotype (borderline significance); F(2, 52) = 5.06, p = 0.0098 for time; F(2, 52) = 0.72, p = 0.4892 for the interaction).

also in 7,017 other papers

Although adult Scn2a +/− mice showed a trend towards significant slower acquisition latencies on day1–4 (two-way repeated measures ANOVA, F(1, 29) = 3.56, p = 0.0693 for genotype (borderline significance); F(5, 145) = 90.04, p < 0.0001 for day; F(5, 145) = 1.1, p = 0.3813 for genotype × day interaction), their performances were comparable to wild-type mice during the probe tests on days 5 and 12.

also in 53,322 other papers