Interestingly, Kaplan-Meier curve analysis showed a strong trend towards a reduced OS in patients with high suPAR levels (e.g. above the 75th percentile) compared to patients with circulating suPAR levels below this cutoff value ( Figure 1C ).
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High baseline soluble urokinase plasminogen activator receptor (suPAR) serum levels indicate adverse outcome after resection of pancreatic adenocarcinoma.
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Interestingly, this analysis revealed a highly significant elevation of circulating suPAR levels in PDAC patients compared to healthy controls ( Figure 1B ).