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Abstracts from the 22nd International Symposium on Signal Transduction at the Blood-Brain Barriers.

Fluids Barriers CNS · 2019 · PMC6737591 · PMID 31506086

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a clear trendno p-value reported
In the cosmetics industry, animal experiments have been banned in the EU, in toxicology there is a clear trend towards alternative methods, and in the pharmaceutical industry a rethinking of the sensible use of animal experiments is slowly beginning.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.