Multi-omic molecular comparison of primary versus metastatic pancreatic tumours.

Genes with modest differences trending towards significance when comparing individual metastatic sites with primary tumours (Fig. 3 ) included STK11, a negative regulator of mTOR signalling via AMPK, 21 which was mutated at a higher frequency in lung lesions (unadjusted p -value = 0.0097).

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While these observations did not achieve significance that survived multiple hypothesis testing, these exploratory results warranted further investigation into possible subgroups.

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