Neuropathy and neural plasticity in the subcutaneous white adipose depot.

After 12 weeks of age, the loss in total inguinal scWAT innervation remained consistent in MUT mice ( Fig 1F ), but TH showed a trend for further decrease in MUT mice aged to 24 weeks ( Fig 1G ).

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Protein expression of the pan-neuronal marker PGP9.5 revealed a decreasing trend with increasing BMI in human scWAT adipose tissue ( Fig 3A ), despite no difference in adipocyte diameter with increasing BMI and no correlation of adipocyte diameter to PGP9.5 levels ( Fig 3B and 3C ), indicating that adipose neuropathy also likely exists in human tissues.

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