The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?

Although this trend of less accumulation of calcium in the coronary arteries in the HT groups did not reach statistical significance, it is consistent with the finding of lower CAC scores after o-CEE (albeit at a somewhat higher dose than in KEEPS) in the E-only group of the WHI 9 and prospective assessments of CAC in postmenopausal women. 10 As KEEPS had excluded women with more significant CAC at screening, the study was underpowered to detect statistical significance for these small changes in CAC among groups.

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